BSID Annual Meeting 2019, Bradford
1st – 3rd April 2019
Norcroft Conference Centre, University of Bradford

BSID 2019 Microsite

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   Monday 1st April – BSID 2019 Clinical Translational Day
 
 

 

 

 

09:30 – 12:00

 

 

 

 

 

 

 

 

 

 

 

OR

09:30 – 12:00

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

12:00

Parallel Monday AM Sessions

Two optional Monday AM sessions for BSID 2019

ATTEND ONE OF THE FOLLOWING:

 

Epigenetics of Skin Workshop (Prebooking essential)

Venue F42 PC-Cluster Room, Richmond Building, University of Bradford

 

Leads: Dr Andrei Mardaryev & Dr Krzys Poterlowicz

An optional add on workshop session aimed at PhD students, postdocs & early career scientists.

 

09:30 – 09:35    Introduction to Workshop (Dr Andrei Mardaryev)

09:35 – 10:15    Introduction to the Galaxy Platform: Analysis of high-throughput
bioinformatic data

Coffee/Tea & Biscuits

 

10:30 – 12:00    Practical session: Analysis of Epigenome-wide Association Studies
using DNA-methylation profiles (in cohort of MAPK kinase inhibitor-
resistant melanoma patients.

 

 

Bench and Bedside: Monday Eczema session – Clinical Translational Day Morning Session
Venue: Norcroft Centre, University of Bradford

Lead: Dr Miriam Wittmann

An optional morning session focusing on eczema. Registration open to all BSID 2019 delegates.

 

09:30 – 10:10    Histamin  – a journey from exploring histamine receptor functions to
current clinical trials targeting H4 receptor in atopic dermatitis
Prof Thomas Werfel, Medizinische Hochschule Hannover, Germany
                          Prof Werfel will present the “Histamine” journey from basic science on the histamine receptors to a currently performed phase II clinical trial targeting the
histamine receptor 4 in atopic dermatitis.

10:10 – 10.50     Atopic Dermatitis. Pollen – autoantigens – pathogens – inflammation
What are the latest recommendation to patients and for whom and
how will the new therapeutics work?
Dr Annice Heratizadeh (Clinican) & Dr Lennart Roesner (Scientist)       

                           Medizinische Hochschule Hannover, Germany

Both have published prominent results on the role of autoantigens, pathogens, the skin’s exposure to pollen, and inflammation and will explain their results in  the context of current pathogenetic understanding, diagnosis and management of atopic dermatitis.

10:50 – 11.20     Discussion
Prof Thomas Werfel, Dr Annice Heratizadeh & Dr Lennart Roesner

 

11:20 – 12:00     Hand Eczema
Which treatment is best for which type of Hand Eczema?
Current evidence and open questions.
Dr Miriam Wittmann, University of Leeds

Registration & Lunch (Norcroft Centre, University of Bradford)

Session A:

CHAIRS:

Skin Club: The Hair follicle – Skin’s multifunctional appendage extraordinaire

Prof Des Tobin & Dr Julie Thornton

 

 

 

 

13:00

 

Coordination of hair regeneration by large-scale signalling

Prof Maksim Plikus, University of California Irvine, USA

 

13:40

 

Epigenetics of hair follicle mesenchymal cells in and out of the niche

Prof Colin Jahoda, Durham University, UK

 

 

14:20

 

 

15.00

Molecular genetic and functional aspects of hair disorders
Prof Regina Betz, University of Bonn, Germany Tea & coffee & commercial exhibition

 

15:40

 

Alopecia areata is associated with increased corticotropin-releasing hormone signalling

Prof Kevin McElwee, Centre for Skin Sciences, University of Bradford, U.K.

 

16:20

 

Clinical trials in trichology: Study design, methods, outcome parameters and new molecules

Prof. Ulrike Blume – Peytavi, Charite Universitätsmedizin Berlin, Germany

 

17:00Open Discussion
17:30 – 18:30Poster session & commercial exhibition

 

19:00Welcome Reception @ the National Science & Media Museum, Bradford City Centre

 

 

 

BSID Annual Meeting 2019 – Tuesday 2ndApril

 

Scientific Session B

 

CHAIRS:               Dr Ryan O’Shaughnessy & Prof Vladimir Botchkarev

 
08.25O1Mechano-sensing and inflammatory signalling in normal and keloid dermal fibroblasts.
R. Ross, J. Maxwell, S.Chandra, X. Liu, M. Lapine, T. Shaw, J. Connelly

 

08.38O2Ageing and UV exposure dysregulate osmolyte-mediated cell volume regulation in human epidermal keratinocytes in vivo.
A.R. Foster, C. El Chami, R. E. B. Watson, C. A. O’Neill

 

08.51O3The SWI/SNF ATP-dependent chromatin remodelling complex controls epidermal keratinocytes migration during human cutaneous wound healing
C. Kellett, R. Bhogal, N. Botchkareva, M. Fessing
09.04O4Keratinocyte nuclear degradation requires AKT1-dependent lamin phosphorylation and the formation of lamin-containing cytoplasmic vesicles

C. Rogerson, K. Odedra, A. Landell-Mills, R. O’Shaughnessy

09.17O5Understanding the role of ABCA12 in the Pathogenesis of Harlequin Ichthyosis
F. Enjalbert, P. Dewan, M. Caley, M. Morse, D. Kelsell, E. O’Toole
09.30O6Laminin 332: Bottom Up Control of The Skin Barrier?
E.M. Jones, S.T. Marsh, R.F. O’Shaughnessy, M. Aumailley, E. Camera, M. Picardo, J.A. McGrath, E.A. O’Toole, M.P. Caley
09.43O7DNA dioxygenases Tet1/2/3 control hair shaft-specific differentiation in the hair follicle keratinocytes via modulation of BMP signalling
G. Chen, Q. Xu, M. Fessing, A. Mardaryev, A. Sharov, G. Xu, V. Botchklarev
09:56Early Career Investigator Award 2019 Recipient  
 09.56 – Introduction
Prof. Des Tobin Chair: British Society for Investigative Dermatology
 10.04 – Presentation   
 10.24 – Q & A   
      
10:30Coffee/Tea & Commercial Exhibition 
 

Scientific Session C


Chairs:                   Dr Daniele Bergamaschi & Dr Mike Fessing
11.00O8Inducible expression of activated β-catenin inhibits papillomas in HK1.ras transgenic mice via increased p53/p21-associated differentiation
A.M.A. Alyamani, J. A Quinn and D. A Greenhalgh
11.13O9Defining the potential of AMBRA1 as a prognostic biomarker for cutaneous Squamous Cell Carcinoma (cSCC)
M. Alexander, J. Armstrong, A. Husain, N. Stefanos, A. McConnell, R. Ellis,
M. Labus, P. Lovat
11.26O10Autophagy modulation reduces the survival and metastasis of drug-resistant human melanoma
S. Verykiou, M. Alexander, N. Edwards, R. Plummer, B. Chaudhry, P. Lovat, D. Hill
11.39O11CD103+ resident memory T cells in primary cutaneous squamous cell carcinoma are associated with metastasis
C. Lai, G. Coltart, A. Shapanis, C. Healy, A. Alabdulkareem, J. Theaker,
A. Al-Shamkhani, E. Healy
 
11.52O12The cell biology of the keratinocyte´s melanin – what happens beyond melanin transfer?
I. Castellano-Pellicena, C.  O´Connor, Mike  Bell, Desmond J.  Tobin
 
12.05Keynote Guest Lecture
Chair: Prof. Vladimir BotchkarevStromal-epithelial cross-talk in inflammatory skin disease and cancer
Prof. Sabine Werner, Institute for Molecular Health sciences, ETH Zurich, Switzerland
 
13.00 – 14.15Lunch, commercial exhibition and Poster session
    
Scientific Session D

 

Chairs:                   Dr Neil Rajan & Dr Gill Westgate

 

14:15O13Type VII collagen and Nesprin 2, LINCing the basement membrane to altered cell cycle and increased DNA damage

S. Marsh, M. P. Caley, V. Martins, T. Corbett-Jones, M. Chen, W. Di, D. Sheer,
J. McGrath, M. Barnes, E. O’Toole

 
14.28O14Single cell RNA-sequencing to chart intracellular cross-talk and molecular processes underpinning lesion formation in atopic eczema

S. Sirvent, A. Vallejo, J. Davies, K. Clayton, Y. Teo, M. Ardern-Jones, M. Polak

 
14.41O15Resolution of atopic dermatitis transcriptomics with an in silico CIBERSORT algorithm reveals that IL4-IL13 modify keratinocytes in both lesional and non-lesional skin whereas an IL17 signature distinguishes chronic AD.

K. Clayton, J. Davies, S. Sirvent, A. Vallejo, R. Ginger, F. Lim, M. Ardern-Jones, M. Polak

 
14.54O16

 

Long non-coding RNA HOTAIR plays an important role in myofibroblast activation and epithelial homeostasis in Scleroderma skin

C. Wasson, R. Ross, G. Abignano, J. Gillespie, F. Del Galdo

 

 
15.07Distinguished Local Lecture

Chair: Prof. Des Tobin Chair British Society for Investigative Dermatology

Born in Bradford – can a research study change a City?

Prof John Wright, Bradford Institute for Health Research, U.K.

 

15.47

 

Tea/Coffee & Commercial Exhibition
16.20 – 17.30Annual General Meeting
18.30Pre-Dinner Drinks @ Salts Mills, Saltaire, Bradford
(incl. visit to David Hockney Gallery)
 

 

19.35

 

19.45

 

 

Guests move to Victoria Hall, Saltaire, Bradford

 

Seated for dinner

 BSID Medal Presentation
19.45

 

Introduction
Prof Des Tobin, Chair British Society for Investigative Dermatology
19.50

 

Citation
Prof Jonathan Barker, St John’s Institute of Dermatology
20.00Medal Presentation
Prof Christopher Griffiths OBE, University of Manchester
20.15Annual Dinner

 

BSID Annual Meeting 2019 – Wednesday 3rd April
    
Scientific session E

 

Chairs:                   Prof Muzlifah Haniffa & Prof Kevin McElwee

 

09.00O17IL-36ɣ acts as a global sensor of epithelial infection following liberation and activation by several epithelial pathogens

T. Macleod, J. Ainscough, S. Herrick, Y. Terao, J. Wenzel, M. Stacey, M. Wittmann

 
09.13O18The Skin Microbiome in Atopic Dermatitis: Interactions Between Bacteria (Staphyloccocus) and Fungi (Alternaria)

M. Hammond, J. Chandra, M. Retuerto, R. Sherif, M. Ghannoum, S. Nedorost, P. Mukherjee

09.26O19A single arm, phase II open label trial to investigate the efficacy and safety of intra-dermal injection of etanercept for remission induction in discoid lupus erythematosus (TARGET-DLE)

M. Md Yusof, M. Wittmann, C. Fernandez, D. Wilson, S. Edward, G. Abignano,A. Alase, L. Sharples, P. Laws, M. Goodfield, E. Vital, P. Emery

 
09.39O20Single cell transcriptomic analysis reveals IRF4 as a key regulator of molecular networks critical for Langerhans immunological activation during migration

J. Davies, A. Vallejo Pulido, S. Sirvent, K. Clayton, J. West, H. Singh, M. Ardern-Jones, B. MacArthur, M. Polak

09.52O21Non-invasive proteomic analysis of inflammatory skin diseases via tape stripping and mass spectrometry.

A. Berekméri, A. Alase, T. Macleod, P. Laws, M. Stacey, M. Wittmann

 

10.05Tea/Coffee, Exhibition & Posters
 

 

Scientific Session F

Chairs:                  Dr Girish Patel & Dr Andrei Mardaryev

 
10.50O22UV Damage Drives Skin Ageing Long After Exposure

C. Earnshaw, E. Nagore, K. Röck, S. Schneider, T. Budden, S. Gurung, S. Craig, C. Griffiths, S. Furney, J. Krutmann, A. Virós

11.03O23Ultraviolet radiation (UVR) induces epigenetic dysregulation in aged but not young skin: an epigenome-wide association study

B. Barnes, D. Gunn, C. Griffiths, R. Watson

11.16O24UV radiation induces ENTPD1 expression which inhibits epidermal DNA damage repair via IL-27 and promotes cutaneous squamous cell carcinoma development

M. Whitley, C. Lai, J. Suwanpradid, C. Reid, R. Rudolph, D. Zelac, W. Havran, J. Cook, D. Erdmann, H. Levinson, E. Healy, A. MacLeod

11.30British Photodermatology Group Guest Lecture
Chair: Dr Angela Tewari

Title:Chronically sun-exposed skin; cultivating the seeds for keratinocyte cancer

Prof Eugene Healy, University of Southampton/ University Hospital Southampton NHS Foundation Trust

 

12.10Break with lunch
 

12.30 – 15.00         A UCB Pharma Sponsored Psoriasis Symposium
(organised in collaboration with the BSID)

15.00BSID 2019 Prizes
15.30Close of meeting
  

On behalf of the BSID Committee, and the local University of Bradford organizing team chaired by Dr Julie Thornton, I look forward to welcome you to Bradford

Professor Des Tobin                                                            

Chair
British Society for Investigative Dermatology

BSID 2019 Microsite